Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.687105
Title: Investigating the effects of dopamine and 3’, 5’-cyclic adenosine monophosphate-regulated neuronal phosphoprotein, 32 kDa (DARPP-32) deletion on adaptive reward-based learning and performance
Author: Mawer, David
ISNI:       0000 0004 5921 9904
Awarding Body: University of Sussex
Current Institution: University of Sussex
Date of Award: 2016
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Abstract:
Dopamine and 3',5'-cyclic adenosine monophosphate-regulated neuronal phosphoprotein (DARPP-32) is a critical mediator of neuroplasticity in striatal medium spiny neurons (MSNs). The work presented in this thesis used a global gene knockout (KO) construct to investigate the role of DARPP-32 in reward-based learning and performance. Global deletion of the DARPP-32 gene disturbed performance during the intertemporal (delay) discounting procedure. DARPP-32 KO mice were less sensitive than their wildtype (WT) littermates during long delays to reinforcement. In comparison to WT mice, DARPP-32 KO mice also developed a risk-sensitive pattern of choices during a probability discounting task. Unlike the effects of DARPP-32 deletion on reinforcement along dimensions of time and risk, DARPP-32 knockout did not affect the degree of effort that subjects were willing to invest during food-reinforced progressive ratio testing. DARPP-32 KO mice also failed to exhibit Pavlovian-to-instrumental transfer and this impairment could not be rescued by administering methylphenidate prior to test. Finally, DARPP-32 KO mice were indistinguishable from WT mice during an amphetamine psychomotor sensitisation study. Overall, the data in this thesis suggest DARPP-32 is involved in adaptive reward-based learning and performance.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.687105  DOI: Not available
Keywords: BF0180 Experimental psychology ; BF0501 Motivation ; BF0699 Genetic psychology
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