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Title: 1H magnetic resonance spectroscopy of γ-aminobutyric acid : methodological development and multimodal application
Author: Mikkelsen, Mark
ISNI:       0000 0004 5915 3597
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2016
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The topic of this doctoral thesis is the magnetic resonance spectroscopy (MRS) of the neurotransmitter γ-aminobutyric acid (GABA). Its scope encompasses areas of MRS of GABA that currently require material methodological improvement and further empirical investigation. Thus, the work presented herein has two overarching objectives. Firstly, to develop MRS of GABA by addressing outstanding methodological limitations of the technique, namely (i) contamination of the GABA signal by signals from macromolecules and (ii) issues regarding the absolute quantification of MRS-measured GABA concentration. Secondly, this thesis describes an investigation of the role of GABA in the haemodynamic response as measured with functional magnetic resonance imaging. This multimodal study both brings together the methodological developments described earlier in the thesis into practical implementation and attempts to address certain unresolved issues with respect to associating GABA concentration with the haemodynamic response.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: BF Psychology