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Title: The prevalence and determinants of non-alcoholic fatty liver disease in childhood and adolescence
Author: Anderson, Emma Louise
ISNI:       0000 0004 5921 0010
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2014
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USS dataset and n=3 ,059 in the blood-based outcomes dataset). For example, the odds of USS liver fat per 100 kcal increase in energy intake at age 3 years were 1.79 (95% CIL 1.14 to 2.79). Associations of absolute macronutrient intake with the liver outcomes were inconsistent, and attenuated to the null after adjustment for total energy intake. Physical activity at ages 12 and 14 years was inversely related to risk of NAFLD in adolescence (n=I,292 in the USS dataset and n=2,612 in the blood-based outcomes dataset), for example the odds of liver fat per 15 minute increase in time spent in moderate to vigorous physical activity at age 12 was 0.55 (95%CI: 0.32 to 0.94). The majority of these observed associations attenuated towards the null upon adjustment for fat mass at the time the liver outcomes were assessed, suggesting that these associations may be, in part, mediated by adiposity in adolescence. These results suggest that risk of NAFLD is common in children and adolescents and that risk of NAFLD is affected by modifiable exposures throughout infancy, childhood and early adolescence. Public health initiatives aimed at promoting healthy growth and adiposity gain from infancy, through a healthy diet and physical activity, are warranted for the prevention of NAFLD.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available