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Title: Novel functionalised, nanoarrays of DNA binding supramolecular helicates
Author: White, Jenifer Christine
ISNI:       0000 0004 5917 4988
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2016
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Work described in this thesis shows the design, synthesis, DNA binding activity and gold nanoparticle interaction of functionalised triple stranded supramolecular helicates. DNA structures and the way molecules recognise and bind to them are reviewed, with specific emphasis on supramolecular compounds. Supramolecular helicates are discussed in detail with consideration of how they may be used as anticancer agents. Nanoparticles, specifically gold nanoparticles are studied, with specific reference to how they are able to enhance anticancer properties of drug molecules and how they may be used to develop potent anticancer therapies. With the formation of three novel supramolecular iron helicates and the incorporation of supramolecular chemistry and nanotechnology, through binding such complexes to the surface of gold nanoparticles, foundations of work in this area are discussed, showing promising results for future research.
Supervisor: Not available Sponsor: University of Birmingham ; Engineering and Physical Sciences Research Council (EPSRC) ; COST (European Cooperation in Science and Technology)
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry ; QH426 Genetics