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Title: Effects of environment and aging on synaptic plasticity
Author: Hogg, Ellen Louise
ISNI:       0000 0004 5917 1322
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2014
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Alzheimer's Disease (AD) is a neurodegenerative disease that causes a severe and global loss of cognitive function. The amyloid cascade hypothesis states that it is the deposition of amyloid Beta ABeta in AD that triggers neuronal dysfunction and cell death in the brain. Traditionally the neurotoxic effects of A [Beta] have been attributed to the buildup of extracellular A [Beta] that causes aberrant synaptic plasticity. However more recently it has been established that A [Beta] accumulates intraneuronaly before the formation of extracellular plaques when mild cognitive impairment can be detected. Therefore exposure to intracellular A[Beta]could be a key step in the early stages of AD pathology.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available