Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.682353
Title: Surface properties and biofilm development associated with dental implants
Author: Al-Radha , Afya Sahib Diab
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2012
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Abstract:
The use of titanium dental implants in oral rehabilitation has been shown to have a high success rate, Despite this fact, failures do occur, One of the causes of implant failure is peri-implantitis. The aim of this research was to investigate the effect of different surface modifications on titanium surface characteristics, and to explore if one or more of these surface characteristics or antimicrobial agents can reduce microbial adhesion and biofilm formation. Also, to identify major bacterial species associated with peri-implant diseases in human subjects. A variety of chemical and physical surface treatments have been undertaken to explore their effects on titanium surface topography and physicochemical properties. The results showed that physicochemical properties of titanium can be altered with wide range of properties, depending on the type of modification. Investigation of the influence of physicochemical properties of various modified titanium surfaces on the adhesion abilities of different oral bacteria showed that the most important surface characteristic associated with reduced bacterial adhesion to smooth surfaces was hydrophobicity with low surface free energy. However, there was no similar association found for formation of mixed species biofilms on the same surfaces. Functionalizing of titanium surfaces with some antimicrobial natural oils resulted in antiplaque activities similar to those exhibited by chlorhexidine. This suggested that some essential oils could be used in the use of novel antimicrobial agents effective with implant materials. The association of specific bacteria with peri-implant diseases was investigated. These ·results showed that implants were influenced by a wide range of species. Fusobacterium spp., and Prevotella spp. may playa role in initiating peri-implant disease. Other species such as Porphyromonas spp. may then contribute to progression of disease. In conclusion, these studies suggest that bacterial adherence can be reduced by modifying titanium surface properties or by application of anti-bacterial agent. The research also emphasizes the importance of good oral hygiene to prevent accumulation of pathogenic bacteria and thus decrease the risk of peri-implant infections and implant loss.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.682353  DOI: Not available
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