Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.682045
Title: The impact of surgery to relieve leg pain on cortical control of trunk and leg muscles
Author: Buisson, Yoann
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2013
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Abstract:
All current chronic low back pain (LBP) treatments have variable long-term efficacy. Changes in the central nervous system pathways controlling trunk and leg muscles (T&L) in LBP have been reported, and this thesis investigated whether surgery (n=24) or conservative management (spinal injections [SIs;n=12] or no treatment [NT;n=18]), impact upon these changes in the long term. 19 healthy controls and 54 LBP patients were recruited. 45 of the LBP patients also had leg pain distal to the knee (LBPLP), 12 of which had radicular pain/radiculopathy at L5 and 12 at S1. Transcranial magnetic stimulation (TMS) was used to evoke a number of outcome measures in electromyographic activity. The first long term TMS T&L reliability study established suitable parameters to assess corticomotor excitability (CE) (i.e. motor evoked potential (MEP) threshold (MTh)) and intracortical inhibition (ICI: i.e. the cortical silent period (cSP)) on 4 occasions, prior and up to 1 year following treatment. LBPLP patients had pain-lateralised and markedly prolonged leg cSPs, which, unlike in SI patients, were gradually normalised in high functional responders to surgery. Significant reductions in leg MThs occurred in high functional responders to surgery at 6 weeks, whilst further reductions occurred in those with excellent leg pain outcome. Tibialis anterior was exclusively sensitive to L5 group ICI&CE changes. By contrast, back muscles in LBP had markedly elevated MTh and altered MEP recruitment; with longer MEPs and more moderate bilaterally prolonged cSPs. Patients who improved had more abnormal baseline CE and ICI. These studies establish patho-anatomically specific (side, root level and likely pathway-specific) cortical changes in leg pain/radiculopathy, which are reversible by successful surgery. More significantly, the distinct ICI and CE profiles found in back and leg muscles may eventually be useful in determining which patients are likely to benefit from surgical intervention.
Supervisor: Strutton, Paul ; McGregor, Alison Sponsor: DISCS Foudation
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.682045  DOI: Not available
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