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Title: Chemoenzymatic approaches to pericosines and related carbasugars
Author: Acaru, Carmen Alina
ISNI:       0000 0004 5372 1733
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2014
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Chapter 1 introduces the concept of enzyme and provides a general overview of biodegradation of aromatic compounds by enzymes. A characterisation of Toluene Oioxygenase (TOO) and the use of arene cis-dihydrodiols in synthesis are also discussed. Finally, the chapter 1 gives a brief description of carbasugars, their occurrence in nature and some of the literature syntheses. Chapter 2 contains the general information associated with the discovery, isolation and biological activities of pericosines, a review of structure elucidation of pericosine A and some of the recent literature syntheses of pericosine A and C. The chemoenzymatic syntheses of pericosines A and C using arene cis-dihydrodiols as starting materials is also discussed. Chapter 3 gives a brief description of isolation and bioactivity of gabosines and a review of the chemical syntheses of MK7607. The chemoenzymatic approach to MK7607 and gabosines 0 and E, discussion of experimental results are also provided. Chapter 4 details the biological activities of pinitol, isolation and structure elucidation of chlorosphaeropsidone. The chemoenzymatic synthesis of pinitol and the effort made towards the total synthesis of the chlorosphaeropsidone are presented. This chapter also examines the strategies for synthesis of opposite enantiomer of bromobenzene-cis-dihydrodiol. Chapter 5 contains full experimental details and references
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available