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Title: Effect of a polyphenol-rich diet on vascular function and other markers of cardiovascular risk
Author: Noad, R. L.
ISNI:       0000 0004 5372 8134
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2014
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Observational and intervention evidence indicates that polyphenol-rich foods, in particular berries and dark chocolate, may influence cardiovascular disease risk. However, there are few polyphenol-specific dietary intervention studies. The aim of this thesis was to test the hypothesis that increasing overall polyphenol dietary intake, through increasing fruit and vegetable, berries, and dark chocolate intake, would improve microvascular function and other markers of cardiovascular risk. The primary endpoint was endothelium-dependent arterial vasodilator responses, assessed by venous occlusion plethysmography. Compliance was assessed using food diaries and biochemical markers of nutritional status. Other measures of cardiovascular risk included lipids, hsCRP, PAI-1, 11-dehydrothromboxane B2 and heart rate variability. A total of 99 volunteers completed the study. The intervention was well-tolerated and markers of compliance indicated good adherence to the diet. Between-group comparison of maximum % response to Ach was significantly improved in the high polyphenol group (p<0.001), with a trend towards a reduction in systolic blood pressure (p=0.059) and 11- dehydrothromboxane B2 (p=0.066), and a significant decrease in total cholesterol (p=0.042). There was no significant effect of the intervention on inflammatory markers and heart rate variability indices. Results were reanalysed with polyphenol-rich foods as a continuous variable. An extra portion of fruit and vegetables and dark chocolate was predicted to promote an absolute increase in the maximum response to acetylcholine of 14.0% and 112.5% respectively.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available