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Title: An autonomous chemically-fuelled rotary motor
Author: Wilson, Miriam Ruth
ISNI:       0000 0004 5372 5099
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2016
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Biological processes commonly use molecular motors to drive chemical systems away from equilibrium thus enabling work to be done. This has inspired efforts to create synthetic rotary motors which mimic the key properties of their biological counterparts, namely autonomy and directionality with the use of a chemical fuel. Thus far, attempts to combine all three properties in a synthetic rotary motor have proven unsuccessful. This thesis describes the design, synthesis and operation of an autonomous, chemically-fuelled, directional rotary motor. In this two-compartment [2]catenane an information ratchet mechanism operates. Directional transport of the small macrocycle around the larger one is promoted by an acylation reaction using a sterically demanding pyridine-based catalyst. To achieve autonomy, conditions for a one-pot, directional, de-acylation/re-acylation reaction were developed. Under autonomous operation conditions the macrocycle displacement was followed by 1H NMR. Chapter One describes the previous strategies that have been employed to realise unidirectional rotary motion in synthetic systems and aims to give the reader an overview of the relevant literature in the field of synthetic rotary motors. Chapter Two describes the concept and design of the project. Previous work which formed the basis for this research is also discussed. The synthesis and successful operation of a molecular information ratchet fuelled by chemical energy is reported. Chapter Three describes the first autonomous, synthetic rotary motor fuelled by chemical energy. The autonomous nature of the operation is determined by 1H NMR, mass spectrometry and HPLC.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available