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Title: Exploring the relationship between dietary intake, nutritional status and the risk of cardiovascular events and overall mortality in the PRIME and Caerphilly cohorts
Author: Lyner, Natalie Lisa Rose
ISNI:       0000 0004 5370 9953
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2015
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Full text unavailable from EThOS. Thesis embargoed until 01 Apr 2020
Diet is recognised as a modifiable risk factor for cardiovascular disease (CVD). Dietary exposure can be examined through assessment of dietary intake or examination of nutrient status. The relationship between dietary intake and disease has traditionally studied individual foods or nutrients but this approach does not allow examination of the synergistic or antagonistic effects of nutrients/foods, as they are consumed in the diet. This has led to a complementary approach to the study of diet and disease: dietary pattern analysis. This thesis aimed to explore the association between two dietary pattern (DP) approaches, 'a priori' and 'a posteriori', with chronic disease risk in two prospective studies (PRIME and Caerphilly). Secondly, it aimed to investigate associations between antioxidant micronutrient status and CVD Incidence and overall mortality risk in PRIME. Genetic variation may influence the absorption, metabolism and uptake of nutrients in the body. A final aim of this thesis was to examine if the status of vitamin C, retinol and carotenolds varied by genotype for a number of single-nuqleotide-polymorphisms (SNPs) In the PRIME study. Both a priori and a posteriori DP approaches supported the importance of broadly healthy dietary patterns and, importantly, dietary variety for health, particularly for mortality outcome~: Strong correlations between some micronutrients make it difficult to determine independent effects, however, mortality risk decreased linearly with increasing status of vitamin C, retinol, a-tocopherol and all carotenoids. CVD incidence was significantly inversely associated with retinol and (3-carotene status. Some evidence existed of an influence of genotype on AO micronutrient status for two out of the four examined SNPs. Phenotype is based on both genotype and environmental exposures and this thesis illustrates the value of examining both of these influencing factors, in a number of ways, In order to gain a better understanding of the complexities of the diet-disese relationship.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available