Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678709
Title: Polymer films containing SERS active metal nanoparticles for therapeutic drug monitoring and forensic analysis
Author: Lee, W. W. Y.
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2014
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Abstract:
The work in this thesis was centred on developing an alternative method for therapeutic drug monitoring based on using microneedle arrays to sample interstitial fluid combined with a SERS active layer for analysis of the sampled fluid. Simple aqueous colloids are too unstable to use in this application so here the colloid was aggregated and then preserved within hydroxyethylcellulose (HEC) films. The films were then tested alongside microneedle arrays, which were prepared and developed by Salvador and Donnelly in the School of Pharmacy, Queen's University Belfast. The principle was that the microneedle arrays would puncture the skin to take up the interstitial fluid containing therapeutic drugs and deliver it to the base plate where the SERS sensing HEC film would be located. The SERS films themselves were found to be effective for the analysis of the target thetapeutic drugs, theophylline and phenytoin. However, when the drugs were taken up by microneedle arrays they were largely trapped within them. The SERS films were found to have a much broader range of potential applications than therapeutic drug monitoring. They were shown not simply to be able to detect conventional aqueous solutions of drugs but they were used as the basis for a novel trace drug detection method. In this method the area to be tested was wiped with a moistened swab which was then contacted with the SERS active film. With mephedrone as a test analyte, drug deposits on surfaces in the Ilg range could be collected and detected. Alternatively, for seized bulk methiopropamine drug samples which had high fluorescence, the films provided a convenient method of quenching the fluorescence and enhancing spectra simultaneously. Finally, the films were also tested for use in analysis of ink samples and proved to be highly effective, providing spectra that allowed various inks to be discriminated.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.678709  DOI: Not available
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