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Title: The regulation of T cell responses by interleukin-27 : implications for autoimmune disease
Author: Young, A.
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2014
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Here presented is a detailed account of two novel findings, as well as further clarification of another known effect of the heterodimeric cytokine IL-27 on T cell biology. The first novel finding describes a potent anti-inflammatory mechanism through the suppression of T cell derived GM-CSF production via IL-27 stimulation. While IL-27 suppressed GM-CSF production by Th1 cells in vitro, it did not influence the production of GM-CSF in committed Th17 cells. il2T'- T cells produced more GM-CSF in response to Toxoplasma gondii infection, suggesting IL-27 signalling regulates T cell derived GM-CSF production in vivo. Furthermore, IL-27 suppressed GM-CSF production by human Thl, but not Th17-polarised cells in vitro, suggesting a conserved mechanism of suppression between species. While IL-27 is a known inducer of IL-10 production in C04+ T cells, the phenotype of these cells remained unknown, with three possible phenotypes proposed (Th1, Tr1cells displayed a Thl phenotype with expression of Thl markers while lacking factors associated with Tr1 and Treg cells.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available