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Title: In vivo analysis of monocyte and macrophage functions in the kidney
Author: Stamatiades, Efstathios
ISNI:       0000 0004 5368 4477
Awarding Body: King's College London
Current Institution: King's College London (University of London)
Date of Award: 2015
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Monocytes and macrophages are phagocytic cells of the innate arm of the immune system. Although initially they were considered just as ‘bug-eaters’ more recent studies suggest that they are effector cells, involved in the homeostasis of the tissues. Yet, more research is needed to understand their functions in vivo. In mice there are two subsets of blood monocytes: Ly6Chi and Ly6Clow monocytes. Ly6Clow monocytes have been studied less than Ly6Chi monocytes and their functions are still elusive. Although kidney macrophages were first described more than 30 years ago still nothing is known about their role in vivo. By exploited intravital imaging and flow cytometry this report showed that Ly6Clow monocytes are housekeepers of the endothelium, scavenging microparticles and cellular debris in the steady state and in inflammation. The results presented herein, further characterized kidney macrophages as effector cells per se and showed, for the first time, that kidney macrophages take up immune complexes in vivo, are activated by immune complexes and recruit monocytes in response to immune complexes. In a nutshell, this work sheds light on the in vivo functions of Ly6Clow monocytes and kidney macrophages, helping us to understand the role of these cells better.
Supervisor: Diebold, Sandra Stephanie ; Geissmann, Frederic Henri Lucien Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available