Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675428
Title: Mechanisms underlying cross education of motor function
Author: Ruddy, Kathy Louise
ISNI:       0000 0004 5371 2327
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2014
Availability of Full Text:
Full text unavailable from EThOS.
Please contact the current institution’s library for further details.
Abstract:
Cross education is the process whereby training one limb gives rise to enhancements in performance of the opposite, untrained limb. It is widely believed that cross education arises due to crossed facilitation of corticospinal pathways during unilateral movement, manifested by a change in excitability measured using transcranial magnetic stimulation over the primary motor cortex (M1) corresponding to the untrained limb. In Chapter 2 we manipulated the visual feedback that was available during training; a factor known to modulate the degree of crossed facilitation. Transfer of performance to the untrained limb was elevated in a group who trained with mirrored visual feedback of the moving limb. However, the same results were not replicated in a later experiment with a larger sample size. The noteworthy finding from this investigation was that despite large performance improvements in the untrained limb, the excitability of corticospinal projections to the relevant task agonist muscle remained unchanged. Changes in muscle activation dynamics in the untrained limb following training were found to be statistically associated with transfer of performance. These modifications, in the absence of a change in the state of M1 pathways, suggests that the neural adaptations that subserve transfer of this task, are located in motor regions 'upstream' from M1. In order to develop more specific hypotheses, Chapter 3 was an investigation of transcallosal white matter fibre pathways between motor cortical regions. This revealed that celiain regions demonstrate superior structural connectivity with the contralateral hemisphere. The investigation culminated in Chapter 4 with a multimodal neuroimaging study. It was revealed that the structural organisation of white matter pathways connecting bilateral supplementary motor area (SMA) was a remarkably good predictor of transfer. The results are interpreted in the context of theories regarding the functional role of SMA, and an emphasis on the task-dependancy of the results is maintained.
Supervisor: Not available Sponsor: Biotechnology and Biological Sciences Research Council
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.675428  DOI: Not available
Share: