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Title: Quantification of chronic fibrosing interstitial pneumonia on computed tomography
Author: Helm, Emma Jane
ISNI:       0000 0004 5371 1527
Awarding Body: University of Warwick
Current Institution: University of Warwick
Date of Award: 2015
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The chronic fibrosing interstitial pneumonias (CFIPs) are diseases which cause progressive and often fatal progressive scarring of the lungs. The recent discovery of the first effective pharmacological therapies for this condition have increased interest in the monitoring of this disease. Due to the complex appearance of the CFIPs on computed tomography, visual quantification of disease severity and extent is limited. The purpose of this thesis was to develop and test a computer algorithm for the automated quantification of pulmonary fibrosis on CT using textural measures known as Minkowski functionals. A computer algorithm was successfully developed and this thesis presents initial results of testing the algorithm on a series of normal scans and on 24 prospectively recruited patients who also underwent a series of other tests including pulmonary function tests and a patient reported symptom questionnaire. The computer output was also compared with the visual assessment of two radiologists. Significant correlations were found between computer calculated lung volume and total lung capacity as measured on pulmonary function tests. We also found a significant correlation between computer calculated fibrosis volume and both gas transfer and forced vital capacity. The radiologists’ visual assessment of fibrosis and the computer estimated fibrosis volume were highly correlated. The novel computer algorithm represents a promising method for quantifying pulmonary fibrosis on CT with potential roles in monitoring disease progression and effects of therapeutic interventions.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: RC Internal medicine