Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674862
Title: The role of the primate frontopolar cortex in mnemonic and choice behaviour
Author: Browncross, Helen Anna
ISNI:       0000 0004 5370 1484
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2014
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Abstract:
The role of the primate frontopolar cortex (FPC) has been investigated using human neuroimaging, lesion and disruption techniques. The results of these investigations have led to a variety of theories regarding the function of this region. It has been linked to the formation of task sets, the performance of multiple tasks, reasoning, context-specific memory (including episodic memory, prospective memory and source memory), attention to internally or externally generated information, mentalising and decision-making. It has not previously been possible to study this area using animal lesion techniques. Here, behavioural experiments conducted using non-human primates (rhesus macaque monkeys) who have received lesions to the frontal pole investigate the contribution of this region to context-specific memory, decision-making and social cognition. Functional magnetic resonance imaging (fMRI) is used to investigate changes in functional network connectivity which occur after lesions to this region. A long-lasting impairment is observed in contextual memory judgements (specifically, how recently a stimulus was encountered) after lesions to the frontal pole. An analysis of the influence of the outcomes of previous choices on behaviour on an analogue to the Wisconsin Card Sorting Test (WCST) indicate that monkeys with lesions to area 10 may be less influenced by the outcomes of an extended history of rewards than control animals. Long-lasting widespread disruption to functional networks after lesions to this region indicate that indirect anatomical connections from this region to posterior areas play a crucial role in the normal functioning of posterior networks.
Supervisor: Buckley, Mark Sponsor: Medical Research Council
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.674862  DOI: Not available
Keywords: Behavioural Neuroscience ; frontopolar cortex ; anterior prefrontal cortex ; episodic memory ; recency memory ; social cognition
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