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Title: Computer aided analysis of inflammatory muscle disease using magnetic resonance imaging
Author: Jack, James
ISNI:       0000 0004 5369 8027
Awarding Body: Loughborough University
Current Institution: Loughborough University
Date of Award: 2015
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Inflammatory muscle disease (myositis) is characterised by inflammation and a gradual increase in muscle weakness. Diagnosis typically requires a range of clinical tests, including magnetic resonance imaging of the thigh muscles to assess the disease severity. In the past, this has been measured by manually counting the number of muscles affected. In this work, a computer-aided analysis of inflammatory muscle disease is presented to help doctors diagnose and monitor the disease. Methods to quantify the level of oedema and fat infiltration from magnetic resonance scans are proposed and the disease quantities determined are shown to have positive correlation against expert medical opinion. The methods have been designed and tested on a database of clinically acquired T1 and STIR sequences, and are proven to be robust despite suboptimal image quality. General background information is first introduced, giving an overview of the medical, technical, and theoretical topics necessary to understand the problem domain. Next, a detailed introduction to the physics of magnetic resonance imaging is given. A review of important literature from similar and related domains is presented, with valuable insights that are utilised at a later stage. Scans are carefully pre-processed to bring all slices in to a common frame of reference and the methods to quantify the level of oedema and fat infiltration are defined and shown to have good positive correlation with expert medical opinion. A number of validation tests are performed with re-scanned subjects to indicate the level of repeatability. The disease quantities, together with statistical features from the T1-STIR joint histogram, are used for automatic classification of the disease severity. Automatic classification is shown to be successful on out of sample data for both the oedema and fat infiltration problems.
Supervisor: Not available Sponsor: Computer Science, Loughborough University
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Computer aided diagnosis ; Computer aided detection ; Myositis ; Machine learning