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Title: Homochiral synthesis of paraconic acid and the biosynthesis of amphotericin B
Author: Crawforth, James Michael
Awarding Body: University of Leicester
Current Institution: University of Leicester
Date of Award: 1996
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Homochiral (S)-(-)-paraconic acid was synthesised in 18% overall yield from (45)-4-isopropyl-2-oxazolidinone using titanium enolate methodology. Paraconic acid was used to synthesise A-factor. A-factor and analogues were fed to a culture of Streptomyces nodosus however no definitive enhancement, or a decrease in the lag time for the onset of metabolite production was observed. Sodium acetate-d3, [1-13C] and [3-13C]-propionate were fed to a culture of Streptomyces nodosus and label incorporation into amphotericin B of 10-15% was observed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available