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Title: Investigating the utility of the WMS-IV(UK) with novel procedures as an assessment tool for accelerated long term forgetting in Temporal Lobe Epilepsy
Author: Nikopaschos, Martha Faye
ISNI:       0000 0004 5364 3560
Awarding Body: University of East London
Current Institution: University of East London
Date of Award: 2015
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Research suggests some individuals with Temporal Lobe Epilepsy (TLE) experience an increased rate of forgetting for new information; currently defined as ‘Accelerated Long-Term Forgetting’ or ALF (Butler & Zeman, 2008). This novel construct goes undetected by standard neuropsychological measures and only becomes apparent after longer testing delays. However, as yet there have been no specific measures developed for the assessment of ALF. Consequentially, it is often undetected in TLE and research (relying on various novel or adapted measures) is yielding inconsistent findings. The present study aimed to build upon the findings of a previous research project (Crowley, 2014) by adapting an existing and widely used neuropsychological measure (Wechsler Memory Scale - Fourth UK Edition [WMS-IVUK]; Wechsler, 2010) in an attempt to assess its utility at detecting ALF in TLE. 25 TLE participants and 26 unaffected controls were administered selected WMS-IVUK subtests with an additional one-week recall and recognition delay. Participants also completed a comprehensive neuropsychological battery of cognitive and non-cognitive measures. Data was analysed at the group and individual level, and the contribution of non-memory cognitive and non-cognitive variables was considered. When analysed at the group level, TLE participants displayed evidence of verbal and visual ALF on selected WMS-IVUK subtests, even when the mediating role of non-memory variables was considered. Individual analysis revealed a range of memory profiles in the TLE group. Some participants displayed primary difficulty in the encoding/retrieval of new information, assessed across standard delays. It was unclear whether these individuals also experienced accelerated forgetting. Other individuals displayed a memory profile consistent with current definitions of ALF and performed worse than controls at the extended delay despite performance being comparable at the standard delay. Evidence of ALF was observed for all three WMS-IVUK subtests, on tasks of recall and recognition. Findings suggest the utility of the WMS-IVUK at detecting ALF in TLE.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (D.Clin.Psy.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available