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Title: Genetic variation in natural populations of Drosophila melanogaster
Author: McKay, James Climie
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1978
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Five natural populations of Drosophila melanogaster from diverse geographical and ecological sites have been studied. Genetic variation within populations and genetic differentiation between populations were high. Two hundred and forty six strains, isogenic for second chromosomas, have been derived from these populations and surveyed for variation in the properties of the enzyme alcohol dehydrogenase (ADH). The majority of variation in ADH activity was attributable to the presence, in all five populations, of two electrophoretic forms of the enzyme. Within electrophoretic classes significant variation existed between populations and between some strains in ADH activity. Two strains showed abnormal ADH activities. Variation in the heat stability of ADH enzyme was almost wholly attributable to the presence of two electrophoretic forms. Only two strains showed best stabilities atypical of their electrophoretic class. The absence of heterogeneity within electrophoretic classes at this locus is discussed in view of the predictions of models of protein variation and recent experimental results. In the four strains exhibiting unusual properties of ADH activity or stability, the loci responsible map in the region of the ADH locus.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available