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Title: Commonalities and differences between schizophrenia and bipolar disorder
Author: McIntosh, Andrew M.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2004
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Schizophrenia and bipolar disorder share many symptoms but are difficult to separate on the basis of treatment response or prognosis. This had led to question their validity as disease entities. The evidence concerning their validity is introduced in chapter 1 of this thesis and chapter 2 discusses the evidence for structural and neuropsychology abnormalities in both disorders, and specifically whether these form a basis by which they can be separated. Particular attention is given to magnetic resonance imaging (MRI) studies in affected individuals and in unaffected family members. Chapter 3 is a systematic review and meta-analysis of structural MRI studies of bipolar disorder, comparing affected patients with both healthy controls and with schizophrenic subjects. Some evidence is found for regions which may separate patients with bipolar disorder from controls and from patients with schizophrenia. Chapter 4 outlines the methods for the main neuropsychological and MRI study of families affected by schizophrenia, bipolar disorder or both. The clinical and neuropsychological results are given in chapter 4 and the MRI results in chapter 5. This study finds some evidence that certain neuropsychological impairments are specific to a family history of schizophrenia. Certain reductions in grey matter, particularly in prefrontal areas, appear to be relatively specific to a genetic liability for schizophrenia. Other regions, particularly the anterior thalamus, may be affected in all patients and relatives. Furthermore these grey matter findings are associated with complementary white matter density reductions. Chapter 6 discusses some of the outstanding issues in terms of the separation of schizophrenia and bipolar disorder, and discusses the future of neuropsychological and brain imaging research in this area.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available