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Title: Echocardiographic/Doppler criteria of normality, the findings in cardiac disease and the genetics of familial dilated cardiomyopathy in Newfoundland dogs
Author: McEwan, J. D.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1999
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Section A, the Introduction, reviews the general literature concerning canine dilated cardiomyopathy, with pertinent references to the human literature. The breed specific manifestations of canine dilated cardiomyopathy are discussed. Section B reviews the literature on the echocardiographic / Doppler diagnosis of specific chamber enlargement and systolic and diastolic function and therefore the diagnosis of dilated cardiomyopathy. Echocardiographic / Doppler data are presented from 223 scans from 165 individual Newfoundland dogs. These were subdivided into the following categories, based on the M-mode echocardiographic results. The Normal group of 86 scans had unremarkable echocardiographic findings. The DCM group (35 scans) had a diagnosis of dilated cardiomyopathy. There were two groups with depressed fractional shortening (dFS), one with dFS less than 18% (29 scans), and the other with dFS between 18 and 20% (24 scans). A group of eight scans had an M-mode diagnosis of left ventricular enlargement without fulfilling other criteria for the diagnosis of DCM. Forty scans had aortic velocities in excess of 1.7 m/s, most of which had additional evidence of subaortic stenosis (SAS). Detailed analysis of the Normal group, encompassing mature Newfoundlands of all ages, identified that age affected echocardiographic parameters. The influence of other independent variables, gender, body weight or surface area and R-R interval, on the echocardiographic parameters of the Normal and other Newfoundland groups are also reported. Comparison between the Newfoundland groups showed significant increase in diastolic and systolic dimensions in the DCM Newfoundlands and normal systolic time intervals compared with the Normal groups. Dogs with dFS or LVE in some cases did progress on serial evaluation to fulfil echocardiographic criteria for the diagnosis of DCM, although the limited time of the study (three years) and the restricted number of repeat evaluations preclude firm conclusions. The SAS group showed left ventricular chamber enlargement and altered geometry relative to the Normal group. Some dogs with an unequivocal echocardiographic / Doppler diagnosis of SAS had no audible heart murmur detected. Section C reviews the literature on human familial dilated cardiomyopathy and the genetics of dilated cardiomyopathy.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available