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Title: Factors affecting the absorption and disposition of frusemide and bumetanide in man
Author: McCrindle, Jennifer
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1996
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Drug absorption, elimination and effect may be influenced by many factors including type of formulation, particle size, dissolution and by the presence of other drugs or food and fluid ingestion. The influence of some of these factors on the absorption and effect of frusemide and bumetanide have been investigated in the present studies. The effect of food on the absorption of oral frusemide (40 mg) was determined in 8 healthy volunteers. Food significantly reduced peak plasma concentrations (2.35±0.49 versus 0.51±0.19 mg/l) and delayed the time to peak. The bioavailability of frusemide was also significantly reduced from 76% fasting to 42% after food. The study was then repeated in 9 healthy volunteers using oral bumetanide (2 mg) given with and without food. The peak concentration was reduced after food (96.9±15.1 versus 36.1±11.5 μg/l) and the time to peak concentration delayed. However the mean bioavailability of bumetanide was not significantly reduced by food. A survey carried out in two medical wards within the Edinburgh Royal Infirmary then provided information on the general use of frusemide and bumetanide and showed that most of the patients were taking a single oral dose of diuretic with or in close proximity to breakfast, a situation which could potentially alter diuretic absorption and effect. Consequently, the effect of hospital breakfast on the absorption and efficacy of frusemide was studied in 10 medical inpatients. However when frusemide was administered 2 hours after breakfast, no significant improvement in area under the plasma concentration time curve, urinary recovery of frusemide or total natriuretic and diuretic response was found.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available