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Title: The role of PPAR-γ receptor agonists in mild asthma
Author: Anderson, John Ross
ISNI:       0000 0004 5349 6441
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2014
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Asthma is complex and heterogeneous condition characterised by airway inflammation, airway hyperresponsiveness, variable airflow obstruction and symptoms including cough, wheeze and breathlessness. Many of those with asthma fail to achieve optimal control and there is a need to identify novel therapeutic targets and improve the way we detect airway inflammation if the burden of asthma is to be reduced. Chapters 1-4 explore whether agonists for the transcription factor, Peroxisome proliferator-activated receptor gamma (PPAR-y) have a role in asthma. We performed a single centre randomised two parallel group, double blind placebo controlled trial over a 12 week period using pioglitazone to activate PPAR-y. This was followed by a series of mechanistic in vitro experiments investigating whether there was evidence of PPAR-y translocation in sputum cells and airway smooth muscle cells.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available