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Title: Functional neuroimaging in subjects at high genetic risk of schizophrenia
Author: Whalley, H.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2005
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There were three main aims of the current study (i) to use fMRI to identify the neural correlates of state and trait effects in high risk individuals, (ii) to determine if it is possible to distinguish those who subsequently become ill from those who remain well via functional imaging, and (iii) to determine if patterns of brain activity change with the transition to illness, or vary with changes in symptomatic status of these individuals. These results are consistent with previous findings in the Edinburgh High Risk Study – what is inherited by the high risk individuals is a state heightened vulnerability manifesting, in the case of functional imaging, as abnormalities in activation and/or connectivity in prefrontal-thalamic-cerebellar and prefrontal-parietal regions. These findings also suggest that there are additional differences seen in those with psychotic symptoms, and to some extent in those who subsequently go on to develop the disorder. These results are not confounded by anti-psychotic medication since all subjects were anti-psychotic naïve at the time of assessment. The lack of findings traditionally associated with the established illness (dorsolateral prefrontal cortex and lateral temporal lobe) indicate these may be specifically associated with the established state, or when performance differences become manifest. Overall therefore these findings reveal information regarding the pathophysiology of the state of vulnerability to the disorder about the mechanisms involved in the development of schizophrenia or schizophrenic symptomatology.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available