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Title: Development of new methods for peptide synthesis
Author: Watson, Christopher
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1994
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The preparation and evaluation of a number of carboxylic acid protecting groups is reported. The preparation of aspartic acid side chain esters of 9-anthracenylmethanol, 1-(9'-anthracenyl0-3-methylbutan-3-o1, 1-4(4'-fluorophenyl)-2-methylpropan-2-o1, dibenzosuberol and 4-methyl-2,6,7-trioxobicyclo[2.2.2]octane are described. The conversion of these into suitably protected Nα- Fmoc derivatives for the solid phase synthesis of peptides has been carried out and the comparison with established protection strategies is discussed. Model compounds of these derivatives have been prepared which have enabled an evaluation to be carried out of the stability of these systems to acidic and basic hydrolysis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available