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Title: Imaging and treatment of acute ischaemic stroke : the application and verification of non-invasive imaging techniques in the investigation and treatment of acute ischaemic stroke
Author: Wardlaw, Joanna Marguerite
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1994
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The purpose of the project which led to the writing of this thesis was to: 1) Establish the accuracy, limitations and practicality of a simple isotope test, the mean Cerebral Transit Time (MCTT), developed in the Western General Hospital, Edinburgh, and its ability to diagnose the pattern of cerebral arterial occlusion in acute ischaemic stroke; 2) Study the effect of early reperfusion of the cerebral infarct on swelling of the infarct in the acute stage, and clinical outcome in patients with symptoms of extensive acute cerebral ischaemia; 3) Perform an overview analysis of thrombolytic therapy for acute ischaemic stroke; 4) Set up a pilot randomised controlled trial of intra-arterial thrombolysis in acute ischaemic stroke. The Thesis is divided into four parts. Part One describes: a) the background to current understanding of the aetiology and pathogenesis secondary treatment of, and possible primary treatments for acute ischaemic stroke; b) the anatomy and physiology of the cerebral circulation; c) imaging methods for investigating the cerebral circulation and brain parenchyma. Part Two describes a study in 120 acute stroke patients. Part Three is the relationship between reperfusion of the infarct shown by TCD, the amount of swelling in the infarct in the acute stag shown by CT brain scan, and clinical outcome. Part Four contains a review of all publications on thrombolysis in stroke patients.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available