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Title: Detection and mapping of quantitative trait loci in domestic farm livestock species
Author: Walling, Grant Anderson
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1998
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The aims of the thesis were to investigate, by simulation, various aspects of the QTL mapping methods and apply the methods to scan the porcine genome for QTLs. The mapping of the porcine genome was achieved using a Meishan x Large White F2 population. These breeds were chosen because they differed significantly for several traits of economic interest. Markers covered approximately 85% of the porcine genome and animals were measured for growth and fatness traits. Chromosomes 4, 7 and 14 had a genome wide significant effect on at least one trait. In all cases the single gene model was significantly better than the polygenic model. The effects on chromosome 4 for growth were in agreement with previous studies notably a similar study using wild boar from Sweden. Chromosome 7 had a large effect on fatness (over 6mm between breeds) and is of considerable interest because the Large White carries the alleles for high fat depth. Chromosome 14 was shown to have a significant effect on growth rate on test. Confidence intervals were produced by the non-parametric bootstrap and were found to be relatively large (in excess of 30cM) for the location on chromosomes 4 and 14. In contrast the confidence intervals on chromosome 7 were smaller and corresponded to the major histocompatilibity complex, a very gene rich region of the genome.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available