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Title: The correlated effects of genetic selection for growth on reproductive fitness
Author: Wahlroos, Heli
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2002
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This study addressed the question of effects of growth selection and inbreeding on reproductive fitness in the first parity of mice. A range of components was analysed in a unique set of inbred mouse lines derived from seven genetically high growth lines and four low growth lines, with the average weight at mating of high and low line females respectively 48g and 15g. The collection of ‘replicated’ growth lines allowed more general conclusions to be drawn about the effects that were investigated. A correlated response of growth selection was observed on litter size. Surprisingly the litter size of the growth lines did not greatly decrease over the period of full-sib matings, but some other traits such as the number of infertile matings were suspected to be showing inbreeding depression. Therefore, an experiment was designed to estimate the correlated effects of growth selection on components of reproductive fitness. The effects of inbreeding were removed at a foetus level by crossing inbred lines and at parental level by producing two-way crosses. Growth selection had a strong effect on the component of reproductive fitness, for example the ovulation rate was on average 17 ova in high and 9 ova in low lines. The regression of ovulation rate on body weight was consistent in different size of females and as not greatly affected by the inbreeding. However, the little size did not have such a strong connection with body weight due to positive regression between embryonic mortality and body weight. The heavier the females were, the lower was the survival rate from ovulated egg to foetus. Also lower pregnancy rates were observed among the heavy females, which would further reduce the expected litter size of heavy females.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available