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Title: Studies in the psychobiology of the nigrostriatal dopamine system in the rat
Author: Uguru-Okorie, D. C.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1979
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This thesis presents experiments designed to ascertain, in the rat, the role of the nigrostriatal DA system in ingestive behaviour and body weight regulation, operant learning, sensorimotor control of behaviour and spatial behaviour. In some experiments a 6-OHDA lesion of the medial forebrain bundle was used to destroy the nigrostriatal DA system on one side; in some other experiments the nigrostriatal system was disrupted post synaptically on one side by injecting kainic acid unilaterally into the striatum. The effects of these lesions were: (a) the 6-OHDA lesion increased food spillage and decreased food intake and body weight; (b) the kainate lesion after some days caused an increase in food intake and body weight; (c) kainate-lesioned, but not 6-OHDA-lesioned, as consistently preferred to operate the contralateral lever in a two-lever Skinner box; (d) both lesions produced a reversal of forepaw preferences when given in the hemisphere opposite to the normally preferred forepaw; (e) after either lesion, rats rotated mainly ipsiversively, but this effect was stronger in 6-OHDA-lesioned as; (f) rats trained 2 wks or 12 wks after 6-OHDA lesion took, on the average, longer time than controls to acquire a food-rewarded lever pressing response; those with a 12-wk-old lesion showed a preference for the ipsilateral forepaw, but those with a 2-wk-old lesion as a group displayed random forepaw use; (g) rats lesioned with 6-OHDA on the side opposite to the normally preferred arm of a T-mase exhibited a reversal of side preferences. In other experiments, intact rats treated chronically with the DA receptor blocker, haloperidol, exhibited reductions of food spillage and food and water intake, and an apparent facilitation of body weight. It is suggested that the nigrostriatal DA system is involved in ingestive behaviour and body weight regulation, learning, sensorimotor control and spatial behaviour. The nature of nigrostriatal dopaminergic involvement is discussed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available