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Title: Regulation of transcription in maedi-visna virus
Author: Sutton, Keith A.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1995
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The ovine lentivirus maedi visna (MVV) is the prototypic lentivirus. MVV causes a chronic disease with a long incubation period. Infection results in a number of symptoms the most notable being dyspnoea and wasting. The lesions are characterised by a massive mononuclear cell infiltration. Following onset of clinical disease there is a progressive increase in symptoms until death occurs. Replication of MVV within the infected animal appears limited throughout the course of infection and virus replication is not readily detected in vivo even within the pathological lesions. In vivo MVV is known to infect predominantly cells of the monocyte/macrophage lineage. The replication of viruses within these cells is dependent on both their differentiation and activation. It is believed that these events lead to an activation of the viral long terminal repeat (LTR) by cellular transcription factors. The nature of these cellular factors remains unclear. However, for the MVV strain 1514 it appears that the cellular transcription factor AP-1, which is activated during macrophage activation, is central to the process. The potential role of other factors remains unknown and to date most work on transcriptional control in MVV has focused on the role of AP-1 in this process. In addition to 1514 (an Icelandic isolate) other, geographically distinct, MVV isolates have also been sequenced: EV-1 (a British isolate) and SA-OMVV (a South African isolate). These three viruses show a number of sequence and structural differences in the LTR. As well as this inter strain variation there is also intrastrain variation in the EV-1 LTR sequences. This variation in sequence included alterations in sequences known to interact with transcription factors in the 1514 LTR. The significance of this variation to the control of transcription in MVV is unknown as only a single LTR sequence, derived from the 1514 strain, has been analysed functionally.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available