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Title: The development of a computer assisted biopsy procedure for early diagnosis of lung cancer
Author: Sutherland, Linda M.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1991
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The diagnosis of peripheral lung lesions is done by pathological resting of tissue samples collected from the lung by needle biopsy. Lesion positional information is obtained by direct measurement of film negatives taken from two perpendicular X-ray views. Accurate positioning of the biopsy needle, based on this information and under manual control, is difficult to achieve. Sampling accuracy of lesions less than 2cm in diameter (those offering the best chance of a cure if accurate diagnosis is obtained) is poor. The aim of this project was to devise a means of accurately sampling small peripheral lesions (less than 2cm diameter) with a computer guided biopsy needle using a 'C-arm' rotatable X-ray machine to supply the positional information. The existing needle biospy technique is evaluated and a practical error analysis done using a developed mechanical analogue of the X-ray and patient arrangement to determine how the technique might best be developed to reveal all the necessary geometrical information. A marker arrangement is developed which will reveal such geometrical information. The possible methods of image analysis which might be applied to obtain the relevant X-ray information from the C-arm T.V. monitor are examined. In view of the complicated X-ray image obtained these techniques are dismissed and a manual technique is developed instead in which the information is input to the computer by the surgeon using a mouse. The technique is evaluated using an optical analogue of the X-ray machine. A biopsy machine, its computer control system and the mechanism by which the biopsy needle is positioned pointing towards the lesion is developed. Accuracy and reproducibility studies of needle positioning are also detailed and indicate that with selected X-ray views needle positioning should lie within 2-5mm of the lesion, the exact error being dependant upon the lesion position and depth relative to the biopsy machine.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available