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Title: Experimental middle cerebral artery occlusion : a study of the effects of controlled hypotension on infarct size, cerebral oedema, and cerebral blood flow in a rat model of focal cerebral ischaemia, and a preliminary evaluation of the effects of immunosuppression by irradiation on the development of cerebral oedema
Author: Strachan, Roger D.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1995
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If changes in medical therapy are to be beneficial after the ischaemic insult, they must prevent either systemic complications such as hypotension or hypoxia, or secondary local complications such as cerebral oedema and raised intracranial pressure. This thesis addresses further aspects of these secondary complications. In a rat model of focal cerebral ischaemia (middle cerebral artery occlusion), it looks at the effect that systemic hypotension has on the extent of cerebral infarction, the development of cerebral oedema, and the regional cerebral blood flow. It demonstrates that following middle cerebral artery occlusion, there are changes in autoregulatory phenomena that are not isolated to the ipsilateral hemisphere. Staining and histological techniques have shown differences in anatomical and physiological areas of ischaemic damage that indicate disparities in perfusion deficit and anatomical infarction. New techniques for precise experimental blood pressure control are introduced, with comments on the variability of infarct size despite accurate blood pressure control, yet clear evidence that even a modest reduction in blood pressure after an ischaemic insult causes significant increases in infarct size and cortical oedema formation. It explains why the maintenance of blood pressure and cerebral perfusion is so important if the extent of the ischaemic damage is to be minimised. Finally, it looks at the possible role of peripheral blood components in the generation of cerebral oedema. Using whole body irradiation techniques to suppress peripheral blood cell counts, it demonstrates that oedema formation following middle cerebral artery occlusion is reduced following such treatment. A better understanding of the immune mechanisms involved following an ischaemic insult to the brain may have major therapeutic implications.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available