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Title: The development and clinical application of part body neutron activation analysis using californium-252
Author: Smith, Michael A.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1978
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Californium 252 sources were used in a clinical environment for neutron activation analysis studies for a period of * years. During this period changes in part body calcium in bone, in response to different treatment regimes, were measured in patients suffering from primary or secondary bond disease. Measurements were performed on peripheral bone, in particular the forearm, using two sources of 252Cf, minimum total activity 56 mCi, and a purpose built partial body counter. Optimisation of the irradiation geometry and the patient irradiation programme enabled calcium measurements to be performed with a precision of between 1.596 and 1.8% and a bone dose less than 3 rem. The following clinical studies were undertaken: the effect of c1-o hydroxyc1.ecalciferol on 19 patients undergoing chronic haemodialysis, the use of vitamin D2 or D3 in the treatment of 33 patients with potential anticonvulsant osteomalacia, the effect of lithium carbonate in 15 patients with manic depression and the efficacy of conventional treatments in combating thyrotoxic osteodystrophy. Apparatus was also development to measure calcium changes in the lumbar spine. Two 252Cf sources of total activity 200 mCi were used for irradiation and a whole body counter for detection of the induced activity. A precision of 2% was obtained for patient measurements, with a bone dose of 1.3 rem.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available