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Title: Cognitive defects associated with long-term, low-level exposure to organophosphate pesticides : a small group study
Author: Ross, C. M.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2007
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Abstract:
Method: The present study compared neuropsychological performance of 25 agricultural workers, exposed to organophosphate (OPs) pesticides in the course of their work with 22 non-exposed healthy volunteers (controls) who were matched to the exposed group for age, gender, years spent in education and level of intelligence. All of the agricultural workers were involved in litigation. Objective: To establish whether agricultural workers with a history of prolonged exposure to OPs show evidence of cognitive impairment and to determine whether the pattern of cognitive deficits relates to exposure history. Findings: A range of cognitive and emotional problems were identified in agricultural workers. Although general intellectual ability was relatively well preserved in the exposed cohort, they obtained lower scores on tests of auditory verbal memory span, verbal learning, verbal fluency, mental flexibility, reading, visuo-spatial skill and information processing speed, than non-exposed controls. In addition, over 70% of the exposed cohort complained of clinically significant levels of anxiety and depression. They also reported a range of physical symptoms, the most prominent being fatigue, aching muscles and joints, headaches, sleep disturbance and irritability. Exposure history varied amongst individuals who seemed to have similar jobs and many appeared to have a history of undiagnosed acute poisoning. This highlights the importance of taking an adequate exposure history. Conclusions: The question of whether low level exposure to OPs causes ill health will never be resolved without agreed definitions of acute versus low level exposure, adequate assessment of exposure history and consideration of individual vulnerability factors or synergistic effects of chemical combinations that may mediate the dose-response relationship.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (D.Clin.Psychol.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.661390  DOI: Not available
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