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Title: Development and application of tandem time-of-flight mass spectrometry
Author: Quiniou, Michel L. M.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2001
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A novel tandem time-of-flight (TOF) mass spectrometer has been developed for studying the photo-induced dissociation of large molecules and elemental clusters. It consists of a linear first stage TOF analyser for primary mass separation and precursor ion selection, and a second orthogonal reflecting field TOF analyser for product ion analysis. The instrument is equipped with a large volume throughput molecular beam source chamber allowing the production of jet-cooled molecules and molecular clusters, as well as elemental clusters, using either a pulsed laser vaporisation source (LVS) or a pulsed arc cluster ion source (PACIS). A second differentially pumped chamber can be used with effusive sources, or for infrared laser desorption of large molecules, followed by laser ionisation. These primary ions can then be irradiated with a second, high energy laser to induce photodissociation. Detailed information about the fragmentation mechanisms can be deduced from the product ion mass spectra. A theoretical overview of the technique of tandem time-of-flight mass spectrometry is presented, together with a detailed description of the experimental procedures and equipment used. In order to assist with the design and optimisation of the instrument a "virtual" mass spectrometer was drawn to scale using the SIMION software program, in order to simulate ion trajectories for differing voltage, geometry's and dimensions of the ion optics. An ion gate was designed and manufactured to provide primary mass selection following the first time-of-flight mass analyser. The device consisted of four layers of interleaved wires; primary ions could be selectively transmitted by application of a fast rising high voltage pulse to the middle set of wires. The mass gate was measured to have a mass resolving power, m/Dm = 30.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available