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Title: Fast network oscillations in the rodent prefrontal cortex in vitro
Author: Gillougley, Claire
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2013
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Fast network oscillations (~15-80 Hz) in the prefrontal cortex (PFC) have been shown to be essential in a number of important cognitive functions including; memory, attention, learning and emotion. Disruption to these network oscillations have been shown to be apparent in a number of psychiatric pisorders including schizophrenia. The presence of oscillations in the PFC in vivo is extensive, however the mechanisms and pharmacology underlying fast network oscillations in the PFC in vitro remains elusive. The aims of this thesis were to establish mechanisms of generating in vitro fast network oscillations in the rat subdivisions of the mPFe, and to investigate the pharmacological mechanisms underlying this activity. Persistent fast network (gamma and betall) frequency oscillations were evoked by three distinct methods in the rat anterior cingulate (AC) and infralimbic (IL) cortices. Persistent fast network activity could be evoked by concomitant application of the oscillogenic compounds carbachol/kainate (ChlKA) at the concentrations 10 )!M and 200nM respectively, or by application of kainate (KA) alone at the concentration of 800 nM. Transient fast network activity was also evoked in the rat AC and IL cortices by the focal application of NMDA [20 mM], which produced fast network oscillatory activity < 1 minute.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available