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Title: The effects of flavonoids-rich foods on cardiovascular health
Author: Tabatabaee, Setareh
Awarding Body: University of Reading
Current Institution: University of Reading
Date of Award: 2012
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Background: Average life expectancy has doubled over the last 200 years and therefore as quantity of life increased it is important to improve the quality of life as well and this can be through the promotion of lifestyle factors linked to providing a better protection against the development of chronic diseases. CVD is the worldwide number one cause, the second most common cause of death in developing countries and the leading cause of disability worldwide. In the UK, diseases of the heart and circulatory system are the main cause of premature (death before the age of 75) and normal death. Death rates for CHD have been falling rapidly in the UK since the late 1970s. However, death rates from CHD in the UK are still among the highest in Western Europe. Atherosclerosis and thrombotic events are the two main pathological features of CVD and the major cause for chronic vascular disease. Endothelium plays an important role in start and progress of atherosclerosis and Nitric oxide (NO) plays a key role in systemic physiological functions of the endothelium. Epidemiological and medical anthropological investigations suggest that flavonoid-rich foods, in particular those rich in flavanols exert cardiovascular health benefits which one of this benefits is through improvement of endothelium derived nitric oxide synthesis and bioavailability. The aim of this thesis was to assess impacts of acute ingestion of blueberry polyphenols, which are mainly anthocyanins and f1avanols, on blood pressure, platelet function and vascular function (through improvement in endothelium-dependant vasorelaxation).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available