Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.657489
Title: Decreasing the prevalence of foot pad dermatitis in growing turkeys
Author: Mayne, R.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2007
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Abstract:
The results from the work carried out as part of this PhD have led to the conclusion that wetness of the litter can induce severe FPD lesions in young turkeys within a very short space of time (less than 48 h) in the absence of significant excreta, regardless of litter type, when compared with birds housed on dry litter. These experiments provided a method by which FPD could be induced rapidly, which allowed for observations and measurements to be made. When birds were housed on wet litter, inflammatory responses became apparent after just 24 h and the severity of the lesions increased with time. The use of this model has been vital to understanding the development of FPD. The practical outcome of this research is that litter must be better managed to improve turkey welfare and decrease the prevalence of FPD. Cell types involved in the development of FPD were identified under the microscope using H & E stain; notably heterophils and eosinophils. Other cells identified were macrophages and T cells (CD4+ and CD8+) which were observed using immunohistochemical staining. The presence of these cells in birds affected by FPD suggested that there was an inflammatory response occurring within the skin of the foot pad. qRT-PCR techniques were employed to identify cytokine expression within turkey foot pad skin. The expression of IFN-γ, IL-1β, IL-6 and IL-8 was considerably greater in birds housed on wet litter when compared with those housed on dry litter, consistent with an inflammatory response. From these data it can be concluded that the reaction occurring in the birds as a result of FPD is an inflammatory one, with no definite evidence of a cell mediated allergic response to an environmental factor.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.657489  DOI: Not available
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