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Title: An investigation of the clot deposition from a flowing blood analogue by means of ultrasonic imaging
Author: Marosek, Keith William
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1995
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A milk preparation has been shown by several previous workers to have potential as a coagulable analogue fluid for the study of flow related thrombosis in vitro. Christy used bodies of revolution in pulsed and steady milk mixture flows, in an attempt to identify the hydrodynamic causes of blood clotting in determinate and simple flow situations. The varying extent of deposition on the downstream-side of test-bodies of different shapes indicated stasis and some aspect of agitation in the vicinity of a surface as the concomitant conditions necessary for clot to occur on that surface. The principal aim of the research reported here was to develop Christy's milk coagulation experiments further, by obtaining more information about deposit growth hence to shed light, by inference, on mechanisms of flow-related thrombus formation. To this end, milk experiment reproducibility was improved, ways to eliminate bubble and wall clot formation were attempted, and the feasibility of ultrasonic imaging as a means of continuously measuring the thickness of deposited clot was assessed and subsequently employed. The use of real-time ultrasonic imaging enabled wall clot deposition, and its influence on milk experiments, to be continuously monitored macroscopically. It may also provide a way of assessing various methods aimed at preventing wall clot formation. The prospective advantages of ultrasonic imaging were not fully realized by the arrangement adopted in these preliminary experiments, but it now appears that ultrasonic imaging could be of use for studying curd deposition on test-objects, with certain recommended modifications to the current arrangement.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available