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Title: Synthesis and self-assembly of nucleobase-containing polymers by RAFT techniques
Author: Kang, Yan
ISNI:       0000 0004 5366 1523
Awarding Body: University of Warwick
Current Institution: University of Warwick
Date of Award: 2015
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This thesis explores the synthesis of nucleobase-containing polymers by both reversible addition-fragmentation chain transfer (RAFT) polymerization and RAFT dispersion polymerization. In addition, self-assembly behavior of nucleobase-containing polymers is also described. Chapter 1 introduces main concepts and techniques used in this thesis. In addition, the study of nucleobase-containing materials is reviewed. Chapter 2 describes the synthesis of nucleobase-containing monomers and the use of RAFT polymerization to prepare nucleobase-containing homopolymers and copolymers. Moreover, the effect of nucleobase-interactions on the resultant copolymer composition was investigated in chloroform and DMF. Chapter 3 investigates RAFT dispersion polymerization of adenine-containing methacrylate monomer and a 1:1 mixture of adenine-containing and thymine-containing methacrylate monomers in both chloroform and 1,4-dioxane. Nucleobase-containing polymers with relatively good control were obtained and a range of nanostructures were observed that were solvent dependent. Chapter 4 investigates RAFT dispersion polymerization of a thymine-containing methacrylate monomer, which displayed different self-assembly behavior to the observations in Chapter 3. A range of parameters affecting the resultant morphologies was additionally studied. Chapter 5 investigates the self-assembly behavior of nucleobase-containing polymers in aqueous solution mainly using a solvent-switch method. Chapter 6 provides a summary of the key findings of Chapters 2 – 5 and outlines the further work.
Supervisor: Not available Sponsor: University of Warwick
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry