Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654276
Title: Observations on the ultrastructure of human tumors, with particular reference to the role of transmission electron microscopy in tumor diagnosis
Author: Mackay, Bruce
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2003
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Abstract:
The thesis begins with a brief account of the historical development of diagnostic electron microscopy. Practical considerations in the procurement and handling of specimens are then discussed. The major part of the thesis is an account and analysis of contributions that electron microscopy has provided in the study and diagnostic evaluation of human tumors, arranged under anatomic systems and structured around data from observations that I have made myself or with collaborators. The thesis concludes with a discussion of the role of diagnostic electron microscopy in surgical pathology. I review practical considerations and detail how the effective use of electron microscopy in a surgical pathology department is enhanced by efficient organization, optimal utilization of technical facilities, integration with other routine diagnostic activities of the department, and liaison with clinical services. I contend that transmission electron microscopy has revealed much valuable data on the structure of normal and neoplastic cells, clarified the classification of certain categories of tumors, yielded insight into histogenesis, elucidated appearances seen in routine light microscopic sections and smears, facilitated correlation of morphology with immunohistochemistry, provided an often invaluable aid in the solution of diagnostic dilemmas, served as an effective resource in the instruction of pathologists in training, and enhanced presentations and publications on surgical pathology topics. The application of electron microscopy in surgical pathology is limited by economic considerations and a dearth of pathologists experienced in ultrastructural studies, but it continues to be a valuable resource in the examination and diagnosis of human tumors, and in research and education in pathology.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.654276  DOI: Not available
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