Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654221
Title: Synthesis of quinolone antibiotics by Diversomer™ technology
Author: MacDonald, Alasdair Arthur
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1995
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Abstract:
The generation of chemical diversity by the parallel synthesis of potential drug candidates has been demonstrated by Parke-Davis' DIVERSOMER Technology. This technology combines solid phase organic synthesis, (SPOS), miniaturization, automation, integration and custom equipment to generate "libraries" of discrete compounds. The research programme involved a detailed analysis of the synthesis of the quinolones, a well-known class of antibacterial agents of which over 6000 compounds are known to date. A solution phase synthesis was developed which was compatible with solid phase reaction conditions and also amenable to parallel SPOS protocols. Results of these studies and the parallel synthesis, isolation, purification and analysis of a quinolone library will be discussed. Additionally, an alternative "solid support" for the SPOS of quinolones will be discussed. Construction of the quinolones with a tetrabenzo[a,c.g.i]fluorene, (Tbf) handle enables controlled adsorption onto and off porous graphitised carbon (PGC). The Tbf/PGC system also has demonstrated utility for automated, parallel purification strategies.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.654221  DOI: Not available
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