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Title: New methods for the repair and assessment of peripheral nerve injury
Author: Lenihan, David V.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2001
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The present study was designed to investigate factors which could influence the regeneration of peripheral nerves which had been cut and repaired using a variety of grafting techniques. These methods were: repair with a microwaved muscle autograft, a freeze-thawed muscle autograft, and several groups where repair involved a controlled release biodegradable glass tube containing a variety of factors which have been shown to influence nerve regeneration. Assessment of all of these experimental groups involved the use of established electrophysiological and morphometric techniques but also the development of new techniques for measuring the conduction velocity of the lowest fibres and the variability of reinnervation at the neuromuscular junction (stimulated jitter). The experiments revealed that the microwave muscle graft provided the structural support needed for regeneration, however difficulties in preparing the graft made its use in the clinical setting doubtful. The controlled release glass tube did not interfere with regeneration an supported similar levels of regeneration when compared with an established surgical technique. Jitter proved to be an excellent and highly discriminatory test for assessment of the progression and quality of reinnervation of skeletal muscle. The potential for using these techniques in the experimental and clinical settings is discussed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available