Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.653721
Title: The epidemiology of Hodgkin's disease, with special reference to EBV status
Author: Lawrence, David James
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2000
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Abstract:
The aim of this study is to examine further the risk factors for HD both in total and in sub-groups by age and EBV status. The focus will be on whether the risk factors for EBV-status and/or age-at-diagnosis subgroups differ. Risk factors related to an infectious aetiology, family health physical activity will be considered. 1) The results of the analysis of the Scandinavian cancer registry data shows a statistically significant seasonal presentation of HD with a peak in January. 2) Greater numbers of childhood infectious illnesses were associated with a lower risk of HD in the total series and EBV +ve and EBV -ve HD in the YHHCCS study. Childhood infectious illness when aged ³5 years were associated with an increased risk of EBV+ve HD and a decreased risk of EBV-ve HD. Infectious mononucleosis (IM) was associated with a significantly increased risk of HD in the total series and this effect was limited to EBV+ve HD. The difference between EBV subgroups was statistically significant for both of these variables. 3) SNEHD results show a significant positive association of tonsillectomy with HD diagnosed age 16-34 years but not at older ages. HD (OR 5.17, 95% Cl 1.12-23.79) or any haematological malignancy (OR 2.39, 95% Cl 1.07-5.38) in a first-degree relative were associated with a significantly increased risk of HD. There were no significant differences between EBV-status subgroups for general or family health variables. Childhood infections aged ³5 years were associated with an increased risk of EBV+ve HD and a decreased risk of EBV-ve HD (difference between EBV-status subgroups significant (p=0.043). Infectious mononucleosis (IM) was associated with a significantly increased risk of HD limited to the 16-34 years age group. The largest effect of IM was for EBV+ve HD presenting age 16-34 years. 4) The results of physical activity analysis show very little evidence of an effect of short-term activity (i.e. persisting for 3-10 years) on risk of HD. Consistent inactivity was associated with an increased risk of HD in the total series and all subgroups. Results did not differ by EBV status.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.653721  DOI: Not available
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