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Title: Studies on Vibrio cholerae
Author: Latif, M. A.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1966
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Cholera in one of the most important health problems of many areas of Asia. Despite extensive research, workers are still confronted with a number of unsolved problems that stand in the way of control and ultimate eradication of the disease. The immediate problems presented by cholera at this time are related to its treatment and its practical control. The clinical and biochemical abnormalities that occur in the cholera patient can be rapidly and consistently corrected by intravenous administration of fluids approximately equal in volume and electrolyte concentration to the fluids lost via the gastrointestinal route. Although treatment by rehydration is good, specific treatment must wait until we know more regarding the mechanism of pathogenicity in cholera. Alternatively, it may be that phage therapy still is worthy of consideration but this is doubtful. The control of cholera depends on several factors. (i) Improvement of sanitation, provision of safe water, satisfactory disposal of excreta and health education of the public to improve personal hygiene are essentials. (ii) Further investigation of the epidemiology of cholera and cholera like diseases will assist control. This demands more research into cholera phages and genetic mechanisms so that epidemics can be traced and understood. (iii) Finally, active immunization may achieve control of cholera, but we meanwhile require more knowledge of mechanisms of pathogenicity so that good protective antigens may be prepared. The writer has therefore investigated the 2 obviously important aspects of (A) The toxins of cholera; (B) The phage, and genetics related to cholera. These studies are reported in Sections I and II of this thesis respectively.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available