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Title: An application of Doppler echocardiography and tissue Doppler imaging in the evaluation of cardiac function of normal cats and cats with hypertrophic cardiomyopathy
Author: Koffas, Haralambos
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2004
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The aims of this study were (1) to produce Doppler echocardiographic criteria of normality in cats; (2) to identify differnces in ventricular function using Doppler echocardiography between normal cats and cats with HCM; (3) to investigate diastolic and systolic function in normal cats and cats with HCM, by means of TDI. There was no significant difference in LV FS% between normal and HCM cats although affected cats tended to have higher FS%. Apart from the E deceleration time of mitral inflow, which was prolonged in HCM cats, neither the E/A of mitral inflow nor the IVRT were different between the two groups. The LV flow propagation velocity was significantly lower in the affected group compared to that in normal. Asymptomatic affected cats had a higher S wave and S/D ratio and a lower D wave of pulmonary venous flow (PVF) than normal cats. The time from the Q wave of the ECG to peak systolic velocities of PVF was significantly prolonged in the HCM than in the normal group. HCM cats showed significantly higher aortic and pulmonic velocities than normal cats. The TDI technique revealed evidence of both diastolic and systolic dysfunction in HCM cats. On pulsed TDI data, diastolic dysfunction was expressed with decreased early diastolic velocities, lower early diastolic acceleration and deceleration, prolonged IVRt and decreased E’/A’, mainly along the longitudinal axis of the heart. This study, for the first time, offers evidence for systolic dysfunction in feline HCM. The data presented here provides reference data for future studies in the investigation and better classification of feline cardiac diseases. The successful application of TDI in cats, despite the very small size of their heart and the inherent high heart rate often encountered in this species, provides evidence for the successful application of the technique in human neonatal hearts and experimental small animal models of human diseases.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available