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Title: Ocular blood flow in untreated ocular hypertension and primary open angle glaucoma
Author: Kerr, Jan M.
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2004
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PURPOSE: To compare ocular and systemic circulation and haematological factors affecting perfusion in groups of untreated ocular hypertensives (OHT) and primary open angle glaucoma patients (POAG) matched for IOP. METHODS: This was a prospective observational study. Twenty seven high risk OGT (IOP>25mmHg), 24 low risk OHT (IOP<26mmHg), 24 POAG patients and 234 normal subjects were recruited. Subjects were admitted for a morning during which the following measurements were made; intraocular pressure, visual fields, sitting standing and supine pulsatile ocular blood flow, scanning laser Doppler retinal blood flow and finger tip laser doppler blood flow. Venous blood was taken for the following; full blood count, manual fibrinogen, D-dimer, prothrombin fragments F1 and 2, von Willebrand antigen and beta-thromboglobin. RESULTS: Pulsatile ocular blood flow: High risk ocular hypertensives (HROHT) were similar to POAG subjects in terms of their pulsatile ocular blood flow and both groups had reduced POBF compared to normal. POAG had a smaller fall in POBF on lying down that the other 3 groups. Scanning laser doppler flow: POAG had reduced blood flow at the optic cup and increased blood flow in the temporal retina compared to HROHT matched for IOP. Finger tip laser doppler flow: No difference in fingertip blood flow was found between HROHT and POAG. Haematology: A small but significant increase in platelets and fibrinogen was seen in POAG compared to normals. There was no differences between HROHT and POAG. CONCLUSIONS: Ocular hypertensives with IOP above 25mmHg have levels of POBF similar to POAG. Differences in the response of POBF to changing posture and the distribution of blood flow in the retina in POAG compared to OHT point to a failure of control of ocular blood flow as a possible factor in the aetiology of glaucoma.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available