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Title: The effects of neurotrophic factors in facial nerve repair
Author: Kelly, Gerard
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2002
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The present work established a model for the electrophysiological assessment of the rat facial nerve and used the rat and the sheep as animal models for facial nerve repair. In the rat facial nerve, after transection and repair of the buccal division, there was an increase in the number of regenerated axons with 10 μg of both CNTF and BDNF administered exogenously near the site of nerve repair, over a period of 14 days (p=0.003). There was no increase in the number of fibres with similar administration of GDNF and NT 4/5. The administration of these neurotrophic factors failed to show any other improvements in electrophysiological or morphometric measurements in the rat nerve. The advantage of increasing the number of fibres after repair is dubious. In the sheep facial nerve three groups of animals were studied. Group 1 underwent nerve division and repair, group 2 underwent nerve division, repair and entubulation with a biodegradable glass tube and group 3 underwent nerve division, repair with administration of neurotrophic factors. In group 3 exogenous administration of 100 μg of CNTF and 50 μg of both BDNF and GDNF, over a period of 28 days, failed to show any improvement in electrophysiological or morphometric measurements. Nerve entubulation also failed to show any improvement in morphometric measurements but did show an increase in minimum conduction velocity. The reason for this was not clear and may be a spurious result. This study provides evidence for the use of CNTF and BDNF to increase the number of fibres after facial nerve repair on the rat. The functional advantage of this is uncertain. At present, the use of these neurotrophic factors cannot be supported in peripheral motor nerve repair.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available